Blar i forfatter "Heinäniemi, Merja"

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    • Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia 

      Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O.; Marquart, Hanne Vibeke; Flægstad, Trond; Forestier, Erik; Jónsson, Ólafur G.; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, Gudmar; Syvänen, Ann-Christine; Nordlund, Jessica (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-08)
      Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification ...

    • Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma 

      Pölonen, Petri; Jawahar Deen, Ashik; Leinonen, Hanna M.; Jyrkkänen, Henna-Kaisa; Kuosmanen, Suvi; Mononen, Mimmi; Jain, Ashish; Tuomainen, Tomi; Pasonen-Seppänen, Sanna; Hartikainen, Jaana M.; Mannermaa, Arto; Nykter, Matti; Tavi, Pasi; Johansen, Terje; Heinäniemi, Merja; Levonen, Anna-Liisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)
      Accumulating evidence suggests that constitutively active Nrf2 has a pivotal role in cancer as it induces pro-survival genes that promote cancer cell proliferation and chemoresistance. The mechanisms of Nrf2 dysregulation and functions in cancer have not been fully characterized. Here, we jointly analyzed the Broad-Novartis Cancer Cell Line Encyclopedia (CCLE) and the Cancer Genome Atlas (TCGA) ...